FGF 23 Decreases Renal NaPi - 2 a and NaPi - 2 c Expression and Induces 1 Hypophosphatemia In Vivo Predominantly Via FGF Receptor 1 2 3
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چکیده
FGF23 Decreases Renal NaPi-2a and NaPi-2c Expression and Induces 1 Hypophosphatemia In Vivo Predominantly Via FGF Receptor 1 2 3 Jyothsna Gattineni, Carlton Bates, Katherine Twombley, Vangipuram 4 Dwarakanath, Michael L. Robinson, Regina Goetz, Moosa Mohammadi 5 and Michel Baum 2 6 7 8 Department of Pediatrics and Internal Medicine 9 10 University of Texas Southwestern Medical Center at Dallas 11 12 Dallas, Texas 75390-9063 13 Center for Cell and Developmental Biology, 14 The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio 15 Department of Zoology 16 Miami University, Oxford, Ohio 17 Department of Pharmacology, 18 New York University School of Medicine, New York, NY 10016 19 20 Running Head: FGF Receptors and Phosphate Homeostasis 21 Send Reprint Requests To: 22 Michel Baum, M.D. 23 Department of Pediatrics 24 U.T. Southwestern Medical Center 25 5323 Harry Hines Blvd. 26 Dallas, Texas 75390-9063 27 PH: (214) 648-3438 28 FAX: (214) 648-2034 29 [email protected] 30 31 Articles in PresS. Am J Physiol Renal Physiol (June 10, 2009). doi:10.1152/ajprenal.90742.2008
منابع مشابه
FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.
Fibroblast growth factor-23 (FGF23) is a phosphaturic hormone that contributes to several hypophosphatemic disorders by reducing the expression of the type II sodium-phosphate cotransporters (NaPi-2a and NaPi-2c) in the kidney proximal tubule and by reducing serum 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] levels. The FGF receptor(s) mediating the hypophosphatemic action of FGF23 in vivo have...
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